Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp240 | Thyroid Cancer - Translational | ECE2018

Orthotopic PDX Mouse Model of humanprimary Undifferentiated/Anaplastic thyroid carcinoma

Chenlo Miguel , Rodrigues Joana , Freire Manuel Narciso Blanco , del Carmen Suarez Farina Maria , Piso-Neira Magali , Cameselle-Teijeiro Jose M , Alvarez Clara V

Undifferentiated/Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and deadly cancers. It is characterized by loss of thyroid expression markers and no response to conventional treatments. ATC incidence is low representing <2% of all thyroid carcinomas. This, together with its high mortality, makes difficult the development of clinical trials. In our previous works, we have developed a system to culture patient-derived thyroid cancer cells (h7H) that is a go...